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What is PKD?

Polycystic kidney disease (PKD) is the most common genetic cause of end-stage renal disease1

PKD is a group of diseases characterized by the accumulation of numerous fluid-filled cysts. Over time, progressive enlargement of these cysts causes a decline in renal function.2

PKD is broadly divided into 3 types2,3

Kidney with late-stage ADPKD

  1. Helal I, Reed B, Schrier RW. Emergent early markers of renal progression in autosomal-dominant polycystic kidney disease patients: implications for prevention and treatment. Am J Nephrol. 2012;36(2):162-167.

  2. Patel V, Chowdhury R, Igarashi P. Advances in the pathogenesis and treatment of polycystic kidney disease. Curr Opin Nephrol Hypertens. 2009;18(2):99-106. doi:10.1097/MNH.0b013e3283262ab0

  3. Harris PC, Torres VE. Polycystic kidney disease. Annu Rev Med. 2009;60:321-337.