ADPKD is an autosomal dominant disease 1
Each child of a person with autosomal dominant polycystic kidney disease (ADPKD) has a 50% chance of inheriting the abnormal gene1
While ADPKD is an inherited condition, the age of onset and rate of progression can be unpredictable, varying from patient to patient, even in the same family.2
ADPKD can progress at different rates2
Depending on the type of mutation and other risk factors at the root of ADPKD2
- Some patients may develop detectable cysts at 20 years of age
- Rapidly progress to end-stage renal disease (ESRD) by age 50 years
- Other patients may have ADPKD or ESRD that progresses more slowly
- May not reach ESRD until 70 years old2
Patients who have a family history of ADPKD can undergo imaging and genetic testing to confirm whether they have the disease.3
Torres VE, Grantham JJ. Cystic diseases of the kidney. In: Taal MW, Chertow GM, Mardsen PA, Skorecki K, Yu ASL, Brenner BM, eds. Brenner & Rector’s The Kidney. Philadelphia, PA: Elsevier Saunders; 2012:1626-1667.
Braun WE. Autosomal dominant polycystic kidney disease: emerging concepts of pathogenesis and new treatments. Cleve Clin J Med. 2009;76(2):97-104.
Harris PC, Torres VE. Polycystic kidney disease, autosomal dominant. In: Adam MP, Ardinger HH, Pagon RA, et al; eds. GeneReviews® [internet]. Seattle, WA: University of Washington; 1993-2018. https://www.ncbi.nlm.nih.gov/books/NBK1246/?report=printable. Updated July 19, 2018. Accessed October 3, 2018.